Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia

Neurobiology of Disease

Melanie Hamann¹  Uwe-Robert Koch²  Angelika Richter³  Rüdiger Köhling³ 

[1] Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, 10195 Berlin, Germany;Institute of Physiology, University of Münster, 48149 Münster, Germany;Department of Epileptology, University of Bonn, 53105 Bonn, Germany;

关键词: Basal ganglia;    Dyskinesia;    Movement disorder;    Slice preparations;    Striatum;   

DOI  :  

来源: DOAJ

【 摘 要 】

Dystonias are movement disorders whose pathomechanism is largely unknown. Dystonic dtsz hamsters represent a model of primary dystonias, where alterations of striatal interneuron density and sodium channel function in projection neurones were described. Here, using cortico-striatal slices, we explore whether also the communication between neocortex and striatum is altered in dtsz hamsters. Field and intracellular recordings were done in dorsomedial striatum. Electrical stimulation was used to mimic neocortical afferents. Neuronal characteristics, synaptic connections, input–output relations and short- and long-term plasticity were analysed. Regarding cellular properties, striatal neurons of affected animals showed no alterations. Concerning network properties, evoked responses at threshold stimulation were mediated by (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors. In dtsz slices, field responses, paired-pulse accentuation and LTP were larger than in control, possibly by an increase in presynaptic release probability at glutamatergic synapses. In summary, the study indicates that a change of cortico-striatal communication is involved in the manifestation of paroxysmal dystonia in the dtsz mutant.

【 授权许可】

Unknown