The Clinical and Serological Effect of a Gluten‐Free Diet in Border Terriers with Epileptoid Cramping Syndrome

Journal of Veterinary Internal Medicine

M. Lowrie²  O.A. Garden⁶  M. Hadjivassiliou¹  R.J. Harvey⁵  D.S. Sanders⁴  R. Powell³ 

[1] Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK;Davies Veterinary Specialists, Hitchin, UK;Powell Torrance Diagnostic Services, Higham Gobion, UK;Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK;Department of Pharmacology, UCL School of Pharmacy, London, UK;Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire, UK

关键词: Dyskinesia;    Gluten hypersensitivity;    Movement disorder;    Neurology;    Paroxysmal nonkinesigenic dyskinesia;   

DOI  :  10.1111/jvim.13643

来源: Wiley

【 摘 要 】

Abstract

Background

Canine epileptoid cramping syndrome (CECS) is a paroxysmal movement disorder of Border Terriers (BTs). These dogs might respond to a gluten-free diet.

Objectives

The objective of this study was to examine the clinical and serological effect of a gluten-free diet in BTs with CECS.

Animals

Six client-owned BTs with clinically confirmed CECS.

Methods

Dogs were prospectively recruited that had at least a 6-month history of CECS based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. Dogs were tested for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies in the serum at presentation, and 3, 6, and 9 months after the introduction of a gluten-free diet. Duodenal biopsies were performed in 1 dog.

Results

Serum TG2 IgA titers were increased in 6/6 BTs (P = .006) and AGA IgG titers were increased in 5/6 BTs at presentation compared to those of controls (P = .018). After 9 months, there was clinical and serological improvement in all BTs with CECS strictly adhering to a gluten-free diet (5/5). One dog had persistently increased antibody titers. This dog scavenged horse manure. On the strict introduction of a gluten-free diet this dog also had an improved clinical and serological response. The diet-associated improvement was reversible in 2 dogs on completion of the study, both of which suffered a relapse of CECS on the re-introduction of gluten.

Conclusions

Canine epileptoid cramping syndrome in BTs is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet.

【 授权许可】

CC BY-NC   
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

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