Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment

Molecules

Scott K. Matafwali¹  Jonathan Katandula²  Larry L. Mweetwa³  Bwalya A. Witika³  Chiluba Mwila⁴  Steward Mudenda⁴  Melissa T. R. Chikukwa⁵  Roderick B. Walker⁵  Pedzisai A. Makoni⁵  Pascal V. Ntemi⁵ 

[1] Department of Basic Sciences, School of Medicine, Copperbelt University, Ndola 10101, Zambia;Department of Biosciences and Chemistry, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield S1 1WB, UK;Department of Pharmacy, DDT College of Medicine, P.O. Box 70587, Gaborone 00000, Botswana;Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka 10101, Zambia;Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa;

关键词: biomimetic drug delivery;    SARS-CoV-2;    COVID-19;    nanotechnology;    cytokine storm syndrome;    nanomedicine;   

DOI  :  10.3390/molecules25245952

来源: DOAJ

【 摘 要 】

The current COVID-19 pandemic has tested the resolve of the global community with more than 35 million infections worldwide and numbers increasing with no cure or vaccine available to date. Nanomedicines have an advantage of providing enhanced permeability and retention and have been extensively studied as targeted drug delivery strategies for the treatment of different disease. The role of monocytes, erythrocytes, thrombocytes, and macrophages in diseases, including infectious and inflammatory diseases, cancer, and atherosclerosis, are better understood and have resulted in improved strategies for targeting and in some instances mimicking these cell types to improve therapeutic outcomes. Consequently, these primary cell types can be exploited for the purposes of serving as a “Trojan horse” for targeted delivery to identified organs and sites of inflammation. State of the art and potential utilization of nanocarriers such as nanospheres/nanocapsules, nanocrystals, liposomes, solid lipid nanoparticles/nano-structured lipid carriers, dendrimers, and nanosponges for biomimicry and/or targeted delivery of bioactives to cells are reported herein and their potential use in the treatment of COVID-19 infections discussed. Physicochemical properties, viz., hydrophilicity, particle shape, surface charge, composition, concentration, the use of different target-specific ligands on the surface of carriers, and the impact on carrier efficacy and specificity are also discussed.

【 授权许可】

Unknown