Chemically Engineered Immune Cell‐Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

Advanced Science

Hélder A. Santos¹  Leila Pourtalebi Jahromi¹  Mohammad‐Ali Shahbazi¹  Amir Azadi²  Aziz Maleki³ 

[1] Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland;Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz 71468‐64685 Iran;Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC) Zanjan University of Medical Sciences Zanjan 45139‐56184 Iran;

关键词: artificial dendritic cell and extracellular vesicle;    biomimetic drug delivery;    engineered immune cell;    immune cell membrane;    nanomedicine;   

DOI  :  10.1002/advs.202002499

来源: DOAJ

【 摘 要 】

Abstract Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell‐based microrobots for hard‐to‐treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface‐engineered immune cells, immunocytes’ cell membranes, leukocyte‐derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on‐demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.

【 授权许可】

Unknown