The Role of Tbx20 in Cardiovascular Development and Function

Frontiers in Cell and Developmental Biology

Yuwen Chen¹  Lu Zhang¹  Ying Liu¹  Chen-Leng Cai¹  Deyong Xiao¹  Bai-Yan Li² 

[1] Cardiovascular Developmental Biology Program, Herman B Wells Center for Pediatric Research, Indianapolis, IN, United States;Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China;

关键词: Tbx20;    heart;    development;    function;    congenital heart defects;   

DOI  :  10.3389/fcell.2021.638542

来源: DOAJ

【 摘 要 】

Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a variety of fundamental roles in cardiovascular development and homeostasis as well as cardiac remodeling in response to pathophysiological stresses. Mutations in TBX20 are widely associated with the complex spectrum of congenital heart defects (CHDs) in humans, which includes defects in chamber septation, chamber growth, and valvulogenesis. In addition, genetic variants of TBX20 have been found to be associated with dilated cardiomyopathy and heart arrhythmia. This broad spectrum of cardiac morphogenetic and functional defects is likely due to its broad expression pattern in multiple cardiogenic cell lineages and its critical regulation of transcriptional networks during cardiac development. In this review, we summarize recent findings in our general understanding of the role of Tbx20 in regulating several important aspects of cardiac development and homeostasis and heart function.

【 授权许可】

Unknown