期刊论文详细信息
Journal of Global Antimicrobial Resistance
Emergence and genomics of OXA-232-producing Klebsiella pneumoniae in a hospital in Yancheng, China
Hong Du1  Jinnan Lv2  Zhichen Zhu2  Haifeng Huang3  Linlin Xu3  Ya Xu3  Chunlei Shi3  Liang Chen4  Yumei Xu5  Min Wang6  Ruifu Yang6 
[1] Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ 07110, USA;Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, PR China;Department of Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng, Jiangsu, China;Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA;Laboratory Department, Shanghai Xuhui Central Hospital, Shanghai, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;
关键词: Klebsiella pneumoniae;    OXA-232;    Clonal dissemination;    Genetic elements;    ST15;   
DOI  :  
来源: DOAJ
【 摘 要 】

ABSTRACT:Objectives: The aims of this study were to infer the phylogenetic relationship of OXA-232-producing Klebsiella pneumoniae (OXA232Kp) strains collected from a Chinese hospital and to determine the composition and genetic background of antimicrobial resistance genes (ARGs) among these strains. Methods: Three non-duplicate OXA232Kp strains were collected from a Chinese hospital. Whole-genome sequencing was used to determine their genome sequences and then a genomic comparison of ARG-carrying genetic elements from the three strains with related sequences was performed. Phylogenetic analysis was conducted by constructing a maximum-likelihood phylogenetic tree. Results: Compared with other Chinese sequence type 15 (ST15)-OXA232Kp strains, the three ST15-OXA232Kp strains in this study could be divided into a single subgroup in phylogenetic relationship. The composition and genetic background of ARGs were identical in the three strains. Three ARG-carrying genetic elements or multidrug resistance (MDR) regions were determined, including a truncated Tn2013-like IS-based transposition unit, a unit transposition Tn6867b and a 40.9-kb MDR region. Conclusion: This study reported clonal dissemination of ST15-OXA232Kp strains carrying multiple ARGs in a Chinese hospital. A comprehensive evolutionary and genomics analysis provided a deeper understanding of OXA232Kp. Further surveillance and study should be advocated to prevent the dissemination of OXA232Kp strains in China.

【 授权许可】

Unknown   

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