Synthesis and Biological Activity of Azine Heterocycle Functionalized Quaternary Phosphonium salts

14th International Conference on Science, Engineering and Technology

自然科学;工业技术

Ravindra, Patil Akshay^1 ; Karpagam, S.^1

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore Tamil Nadu, India^1

关键词: Anti-bacterial activity;    Bactericidal activity;    Gram-negative bacteria;    Gram-positive bacterium;    Klebsiella pneumoniae;    Phosphonium salts;    Staphylococcus aureus;    Structural characterization;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022017/pdf
DOI  :  10.1088/1757-899X/263/2/022017

来源: IOP

【 摘 要 】

Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal activity against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). Quinoline functionalized phosphonium has shown more antibacterial activity than pyrazine and quinoxaline.