Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

Sensors

Hao Huang¹ 

[1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;

关键词: matrix metalloproteinase-9;    biomarker;    cancers;    biosensor;    cancer detection;    matrix metalloproteinases;   

DOI  :  10.3390/s18103249

来源: DOAJ

【 摘 要 】

As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.

【 授权许可】

Unknown