MiR-101: a potential therapeutic target of cancers

American Journal of Translational Research

Cen-Zhu Wang¹  Fei Deng² 

[1] Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P. R. China;School of Clinical Medicine, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221004, P. R. China

关键词: miR-101;    cancers;    biomarker;    therapeutic targets;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

MicroRNAs (miRNAs) are small noncoding RNAs that could regulate gene expressions transcriptionally or post-transcriptionally through binding to 3’ untranslated region (3’UTR) of target messenger RNAs (mRNAs), which were identified to be associated with tumorigenesis in various neoplasms. Among them, miR-101, encoded by two precursor transcripts (miR-101-1 and miR-101-2), was recognized to serve as a tumor suppressor via targeting critical oncogenes or anti-oncogenes. Additionally, studies have shown that miR-101 was participated in multiple cancer-related biological processes, including proliferation, apoptosis, angiogenesis, drug resistance, invasion and metastasis. In this review, we aim to summarize the function of miR-101 in different biological processes by figuring out the underlying target gene networks and explore its potential role as a biomarker in diverse neoplasms, which will provide a brand-new insight in molecular targeting cancer treatment.

【 授权许可】

CC BY-NC