The progress of circular RNAs in various tumors

American Journal of Translational Research

Siying Zhou¹  Yunjie He²  Jinyan Wang³  Dan Wang⁴  Qian Zhang⁵  Sujin Yang⁶  Hui Wang⁷ 

[1] Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China;Department of Breast Cancer Pathology and Research Laboratory, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;Department of General Surgery, Southeast University Medical School, Nanjing 210009, China;Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China;Department of Radiation Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China;Jiangsu Jiankang Vocational College, Nanjing 210000, China;The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China

关键词: circRNAs;    cancers;    biomarker;    therapeutic targets;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Circular RNAs (circRNAs), a novel type of non-coding RNAs, presented as covalently closed continuous loops. Recent researches had found that circRNAs could function as microRNA sponges, regulators of gene transcription and encoding proteins. They were relatively stable and expressed widely in cytoplasm, which played important roles in carcinogenesis of cancers, such as esophageal cancer, gastric cancer, colorectal cancer, hepatocarcinoma, bladder cancer, glioma, breast cancer, osteosarcoma and so on. Furthermore, they were involved in many biological functions, like cell proliferation, drug resistance, cell cycle, invasion and metastasis. Therefore, the further studies were meaningful on the mechanism of cancers and circRNAs. In the review, we will summarize the current biogenesis of circRNAs and the roles of them in various cancers, which might be a novel biomarker and therapeutic avenue.

【 授权许可】

CC BY-NC