Agastache rugosa Kuntze extract, containing the active component rosmarinic acid, prevents atherosclerosis through up-regulation of the cyclin-dependent kinase inhibitors p21WAF1/CIP1 and p27KIP1

Journal of Functional Foods

Jin Yeul Ma¹  Joo-Hui Han²  Jung-Jin Lee³  Min Jung Gu³  Ji-Hye Lee³  Won-Kyung Cho³ 

[1] Corresponding authors.;Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea;Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 701-300, Republic of Korea;

关键词: Anti-proliferative activity;    Agastache rugosa Kuntze;    Cell cycle;    Cyclin-dependent kinase inhibitor;    Rosmarinic acid;   

DOI  :  

来源: DOAJ

【 摘 要 】

Agastache rugosa (Fisch. & C.A. Mey.) Kuntze (A. rugosa), commonly known as Korean mint, has traditionally been used for both food and medicine, depending on which part of the plant is used. We investigated the anti-proliferative activities of A. rugosa extract in vascular smooth muscle cells (VSMCs) and analysed several molecular pathways to determine the active component of the extract. A. rugosa extract inhibited PDGF-BB-stimulated VSMC proliferation and DNA synthesis. A. rugosa extract caused arrest of the cell cycle at the G0/G1 transition by up-regulating the levels of p21WAF1/CIP1 and p27KIP1. Among the components of the A. rugosa extract reported in a previous study, rosmarinic acid (RA) only inhibited DNA synthesis and dose-dependently suppressed PCNA expression. These results indicate that A. rugosa extract, which includes the active component RA, demonstrates anti-proliferative activity by arresting the cell cycle at the G0/G1 phase through the upregulation of p21WAF1/CIP1 and p27Kip1 expression.

【 授权许可】

Unknown