SNP Variation of RELN Gene and Schizophrenia in a Chinese Population: A Hospital-Based Case–Control Study

Frontiers in Genetics

Xia Luo¹  Li Xue³  Yan-Wei Shi⁴  Hu Zhao⁴  Si Chen⁵  Jian-Huan Chen⁶ 

[1] Department of Psychiatry, Shantou University Medical College, Shantou, China;Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China;Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Sun Yat-sen University, Guangzhou, China;Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China;Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China;

关键词: RELN;    schizophrenia;    SNP;    association analysis;    quantitative trait loci analyses;    psychiatric symptoms;   

DOI  :  10.3389/fgene.2019.00175

来源: DOAJ

【 摘 要 】

Aims: We aimed to explore whether RELN contributes to the vulnerability and severity of clinical symptoms of schizophrenia (SZ) in a Chinese population.Methods: The following were conducted in an adult Han Chinese population from southern China: case–control association analyses of 30 representative single nucleotide polymorphisms (SNPs) that were screened according to specific programs based on bioinformatics tools and former research and quantitative trait locus analyses with SNPs and psychiatric symptoms evaluated with the positive and negative symptoms scale.Results: A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ2 = 29.024, p = 6.42E-04, pBonf = 0.017), and the T-C-T-C haplotype was a protective factor for SZ (OR = 0.050, 95% CI = 0.004–0.705). Moreover, the 4-SNP haplotype showed a significant association with G16 (active social avoidance) after false discovery rate correction (χ2 = 28.620, p = 1.697E-04, pFDR = 0.025). In addition, P7 (hostility) was related to the haplotype comprising rs2229864, rs2535764, and rs262355 (χ2 = 31.424, p = 2.103E-05, padjustment = 0.019) in quantitative trait loci analyses.Conclusion: Overall, this study showed several positive associations between RELN and SZ, as well as psychiatric symptoms, which not only supports the proposition that RELN is a susceptibility gene for SZ but also provides information on a genotype-phenotype correlation for SZ in a Chinese population.

【 授权许可】

Unknown