International Journal of Molecular Sciences | |
Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity | |
Ivan Kiselev1  Vitalina Bashinskaya1  Olga Kulakova1  Natalia Baulina1  Ekaterina Popova2  Alexey Boyko2  Olga Favorova1  | |
[1] Dep. of Molecular Biology and Medical biotechnology, Pirogov Russian National Research Medical University, Moscow 117997, Russia; E-Mails:;Dep. of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, Moscow 117997, Russia; E-Mails: | |
关键词: multiple sclerosis; microRNA; SNP; association analysis; susceptibility; MSSS; | |
DOI : 10.3390/ijms160820067 | |
来源: mdpi | |
【 摘 要 】
Multiple sclerosis (MS) is an autoimmune neuro-inflammatory disease arising from complex interactions of genetic, epigenetic, and environmental factors. Variations in genes of some microRNAs—key post-transcriptional regulators of many genes—can influence microRNAs expression/function and contribute to MS via expression changes of protein-coding target mRNA genes. We performed an association study of polymorphous variants of
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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