How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

Frontiers in Microbiology

Douwe van Sinderen¹  Margerita Dall’Asta²  Daniele Del Rio²  Beatriz Jimenez³  Samantha Lodge³  Alice Viappiani⁴  Marta Mangifesta⁴  Francesca Turroni⁵  Sabrina Duranti⁵  Marco Ventura⁵  Christian Milani⁵  Leonardo Mancabelli⁵  Gabriele A. Lugli⁵  Chiara Ferrario⁵  Giulia Alessandri⁵  Andrea Sgoifo⁶  Luca Carnevali⁶  Rosario Statello⁶ 

[1] APC Microbiome Institute and School of Microbiology, National University of IrelandCork, Ireland;Department of Food and Drug, University of ParmaParma, Italy;Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College LondonLondon, United Kingdom;GenProbio s.r.l.,Parma, Italy;Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of ParmaParma, Italy;Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of ParmaParma, Italy;

关键词: diet;    microbiota;    dietary fibers;    rat model;    acetate;    succinate;   

DOI  :  10.3389/fmicb.2017.01749

来源: DOAJ

【 摘 要 】

The composition of the gut microbiota of mammals is greatly influenced by diet. Therefore, evaluation of different food ingredients that may promote changes in the gut microbiota composition is an attractive approach to treat microbiota disturbances. In this study, three dietary fibers, such as inulin (I, 10%), resistant starch (RS, 10%), and citrus pectin (3%), were employed as supplements to normal chow diet of adult male rats for 2 weeks. Fecal microbiota composition and corresponding metabolite profiles were assessed before and after prebiotics supplementation. A general increase in the Bacteroidetes phylum was detected with a concurrent reduction in Firmicutes, in particular for I and RS experiments, while additional changes in the microbiota composition were evident at lower taxonomic levels for all the three substrates. Such modifications in the microbiota composition were correlated with changes in metabolic profiles of animals, in particular changes in acetate and succinate levels. This study represents a first attempt to modulate selectively the abundance and/or metabolic activity of various members of the gut microbiota by means of dietary fiber.

【 授权许可】

Unknown