The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials

Cell Transplantation

Reviews

Emanuela Mazzon¹  Placido Bramanti¹  Serena Silvestro²  Giovanni Schepici² 

[1] IRCCS Centro Neurolesi “Bonino Pulejo”, Messina, Italy;IRCCS Centro Neurolesi “Bonino Pulejo”, Messina, Italy;Both the authors contributed equally to this article;

关键词: multiple sclerosis;    microbiota;    fecal microbiota transplantation;    diet;   

DOI  :  10.1177/0963689719873890

 received in 2019-05-08, accepted in 2019-08-13,  发布年份 2019

来源: Sage Journals

【 摘 要 】

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and degenerative disease that affects the central nervous system. A recent study showed that interaction between the immune system and the gut microbiota plays a crucial role in the development of MS. This review reports the clinical studies carried out in recent years that aimed to evaluate the composition of the microbiota in patients with relapsing–remitting MS (RR-MS). We also report what is available in the literature regarding the effectiveness of fecal microbiota transplantation and the role of the diet in restoring the intestinal bacterial population. Studies report that patients with RR-MS have a microbiota that, compared with healthy controls, has higher amounts of Pedobacteria, Flavobacterium, Pseudomonas, Mycoplana, Acinetobacter, Eggerthella, Dorea, Blautia, Streptococcus and Akkermansia. In contrast, MS patients have a microbiota with impoverished microbial populations of Prevotella, Bacteroides, Parabacteroides, Haemophilus, Sutterella, Adlercreutzia, Coprobacillus, Lactobacillus, Clostridium, Anaerostipes and Faecalibacterium. In conclusion, the restoration of the microbial population in patients with RR-MS appears to reduce inflammatory events and the reactivation of the immune system.

【 授权许可】

CC BY-NC   
© The Author(s) 2019

【 图 表 】

Figure 1.