Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer

Biomedicine & Pharmacotherapy

Yunlin Wei¹  Xiuling Ji²  Liguo Xie²  Qi Zhang² 

[1] Correspondence to: Department of Life Science and Technology, Kunming University of Science and Technology, No. 727, Jingming South Road, Wujiaying Street, Chenggong District, Kunming, Yunnan, 650500, China.;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;

关键词: Curcumin;    Photodynamic therapy;    Anticancer;    Apoptosis;    Mitochondria;    Cell cycle;   

DOI  :  

来源: DOAJ

【 摘 要 】

Curcumin, a phytochemical derived from the rhizome of turmeric (Curcuma longa L.), has a broad group of substances with antibacterial, anti-inflammatory, anti-oxidant, anticancer activities. The anticancer activity of curcumin and its derivatives are mainly related to its regulation of signal transduction pathways. However, due to the low oral availability of curcumin, fast metabolism and other pharmacokinetic properties limit the application of curcumin in the treatment of cancer. Evidence suggests that curcumin combined with photodynamic therapy can overcome the limitation of curcumin's low bioavailability by acting on apoptosis pathways, such as B-cell lymphoma 2 (Bcl-2) and caspase family, and affecting cell cycle. This paper reviews the structure and pharmacokinetics of curcumin, focusing on the anticancer activity of curcumin combined with photodynamic therapy and the effects on cancer-related signal pathways.

【 授权许可】

Unknown