Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling

Cell Communication and Signaling

Lei Jiang¹  Xiaodong Zhang²  Qianqian Zheng³  Jian Gao³  Yan Li⁴ 

[1] Department of General Surgery, Affiliated Hospital of Jinzhou Medical University;Department of General Surgery, Beijing Friendship Hospital, Capital Medical University;Department of Pathophysiology, College of Basic Medical Science, China Medical University;Department of Radiotherapy, The First Affiliated Hospital of Jinzhou Medical University;

关键词: Extracellular vesicles;    Tumor microenvironment;    Angiogenesis;    Remodeling;    Targeted therapy;   

DOI  :  10.1186/s12964-022-00904-5

来源: DOAJ

【 摘 要 】

Abstract Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling. Video abstract

【 授权许可】

Unknown