The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy

Molecular Cancer

Tingting Huang¹  Chunli Song¹  Yiwen Zhou¹  Yang Li²  Ligang Xia²  Lei Zheng³ 

[1] Department of Clinical Laboratory Medicine, Shenzhen Hospital, Southern Medical University;Department of Gastrointestinal Surgery, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital;Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University;

关键词: Gastric cancer;    Extracellular vesicles;    Exosomes;    Tumor microenvironment;    Drug resistance;   

DOI  :  10.1186/s12943-019-0967-5

来源: DOAJ

【 摘 要 】

Abstract Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids such as plasma, saliva, breast milk, cerebrospinal fluid, semen, urine, lymphatic fluid, amniotic fluid, sputum and synovial fluid. EVs deliver almost all types of biomolecules such as proteins, nucleic acids, metabolites, and even pharmacological compounds. These bioactive molecules can be delivered to recipient cells to influence their biological properties, modify surrounding microenvironment and distant targets. The extensive exploration of EVs enhances our comprehension of GC biology referring to tumor growth, metastasis, immune response and evasion, chemoresistance and treatment. In this review, we will sum up the effects of GC-derived EVs to the tumor microenvironment. Moreover, we will also summarize the function of microenvironment-derived EVs in GC and discuss how the bidirectional communication between tumor and microenvironment affect GC growth, metastatic behavior, immune response, and drug resistance. At last, we prospect the clinical application viewpoint of EVs in GC.

【 授权许可】

Unknown