A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging

Journal of Nanobiotechnology

Kun Qian¹  Hongdan Li²  Liang Zhao³  Jin Chen³  Yifeng E³  Yao Qi³  Yijie Shi³ 

[1] Department of Chemistry, Jinzhou Medical University;Life Science Institute, Jinzhou Medical University;School of Pharmacy, Jinzhou Medical University;

关键词: Reactive oxygen species;    Zeolite;    Hydrogel;    Pluronic F127;    Chitosan;   

DOI  :  10.1186/s12951-021-01151-5

来源: DOAJ

【 摘 要 】

Abstract Background As recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site would be significant. Experimental design In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote diabetic wound healing via the neutralization of detrimental factors such as inflammatory cytokines and ROS. Results The cerium (Ce)-doped biotype Linde type A (LTA) zeolite nanoparticles synergistically eliminated mitochondrial ROS and neutralized free inflammatory factors, thus remodeling the anti-inflammatory microenvironment of the wound and enhancing angiogenesis. Moreover, the thermoreversible hydrogel composed of Pluronic F127 and chitosan demonstrated strong haemostatic and bactericidal behavior. Conclusions In conclusion, the obtained thermoreversible, antibacterial, zeolite-based nanoparticles loaded hydrogels represent a multi-targeted combination therapy for diabetic wound healing. Graphical Abstract

【 授权许可】

Unknown