A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging

Journal of Nanobiotechnology

Kun Qian¹  Hongdan Li²  Jin Chen³  Yao Qi³  Yifeng E³  Yijie Shi³  Liang Zhao³ 

[1] Department of Chemistry, Jinzhou Medical University, 121000, Jinzhou, People’s Republic of China;Life Science Institute, Jinzhou Medical University, 121000, Jinzhou, People’s Republic of China;School of Pharmacy, Jinzhou Medical University, 121000, Jinzhou, People’s Republic of China;

关键词: Reactive oxygen species;    Zeolite;    Hydrogel;    Pluronic F127;    Chitosan;   

DOI  :  10.1186/s12951-021-01151-5

来源: Springer

【 摘 要 】

BackgroundAs recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site would be significant.Experimental designIn our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote diabetic wound healing via the neutralization of detrimental factors such as inflammatory cytokines and ROS.ResultsThe cerium (Ce)-doped biotype Linde type A (LTA) zeolite nanoparticles synergistically eliminated mitochondrial ROS and neutralized free inflammatory factors, thus remodeling the anti-inflammatory microenvironment of the wound and enhancing angiogenesis. Moreover, the thermoreversible hydrogel composed of Pluronic F127 and chitosan demonstrated strong haemostatic and bactericidal behavior.ConclusionsIn conclusion, the obtained thermoreversible, antibacterial, zeolite-based nanoparticles loaded hydrogels represent a multi-targeted combination therapy for diabetic wound healing.Graphical Abstract

【 授权许可】

CC BY