Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

Revista da Sociedade Brasileira de Medicina Tropical

关键词: M. tuberculosis;    Drug resistance;    Gene mutations;    Gene sequencing;   

DOI  :  10.1590/0037-8682-0728-2020

来源: DOAJ

【 摘 要 】

AbstractINTRODUCTION: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.METHODS: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.RESULTS: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).CONCLUSIONS: The proportion of mono-SM-resistant TB among new patients was higher.

【 授权许可】

Unknown