Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

Sociedade Brasileira de Medicina Tropical. Revista

article

Zeng Mei Chun¹  Jia Qing Jun² 

[1] Zhejiang University, College of Medicine, The First Affiliated Hospital, Department of Pathology;Hangzhou Center for Disease Control and Prevention, Department of TB Control and Prevention

关键词: M;    tuberculosis;    Drug resistance;    Gene mutations;    Gene sequencing;   

DOI  :  10.1590/0037-8682-0728-2020

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Introduction: Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide. Methods: MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced. Results: Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SMresistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V). Conclusions: The proportion of mono-SM-resistant TB among new patients was higher.

【 授权许可】

CC BY