A new mode of probiotic therapy: Specific targeting

Journal of Functional Foods

Zehava Uni¹  Michael Friedman²  Einat Amit-Romach²  Zippi Berkovich³  Ram Reifen⁴  Itzhak Aizenberg⁵ 

[1] School of Nutritional Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, 76100 Rehovot, Israel;Department of Animal Science, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, 76100 Rehovot, Israel;Koret Veterinary Hospital, Bet Dagan, The Hebrew University of Jerusalem, 76100 Rehovot, Israel;School of Nutritional Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, 76100 Rehovot, Israel;School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 76100 Rehovot, Israel;

关键词: Colitis;    Probiotics;    Targeting;    Therapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Luminal bacteria are the most probable inducers of inflammatory bowel disease (IBD). The intestinal microbiota can be modified by probiotics, which reduce symptoms in IBD, via stimulation of the intestinal immune system. We aimed to evaluate the effects of oral and rectal administration of probiotics, on the morphology, gene expression, and microbial ecology of the colon, in a rat trinitrobenzenesulfonic acid (TNBS) model. Colitis was induced with simultaneous rectal or oral administration of probiotics. Both routes of introduction significantly increased the relative amounts of Lactobacillus spp. Rectal introduction almost eradicated damage to the tissue, while enteral introduction only improved it. Only rectal probiotics significantly decreased myeloperoxidase activity, and altered mucin and Toll-like receptor mRNA expression in the colon, to values close to control. We suggest that targeted introduction should be considered not only for probiotics but also for nutrients such as amino acids and vitamins into the colon and intestine.

【 授权许可】

Unknown