Targeted delivery of biological agents

QH301 Biology

Greig, Jenny A. ; Baker, Andrew H.

University:University of Glasgow

Department:Institute of Cardiovascular and Medical Sciences

关键词: Adenovirus, Anti-oxidant, Targeting;   

Others  :  http://theses.gla.ac.uk/1386/1/2009GreigPhD.pdf

来源: University of Glasgow

【 摘 要 】

Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity.Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects.Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector.This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.