Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E

Clinical and Molecular Allergy

Ghada Bin Saif¹  Ahmad A. Al Robaee²  Abdullateef A. Alzolibani²  Zafar Rasheed³  Tarek Salem³  Ragaa H. Salama³  Alaa Abd El-Moniem⁴  Maha Elkholy⁴  Khaled Zedan⁵  Ahmed A. Ahmed⁶ 

[1] Department of Dermatology, College of Medicine, King Saud University;Department of Dermatology, College of Medicine, Qassim University;Department of Medical Biochemistry, College of Medicine, Qassim University;Department of Medicine, College of Medicine, Qassim University;Department of Pediatrics, College of Medicine, Qassim University;Research Center, College of Medicine, Qassim University;

关键词: Atopic disorders;    Pediatric patients;    Atopic dermatitis;    Allergic rhinitis;    Bronchial asthma;    Filaggrin;   

DOI  :  10.1186/s12948-018-0102-y

来源: DOAJ

【 摘 要 】

Abstract Background Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggrin protein, eosinophil major basic protein (MBP) and immunoglobulin E (IgE) to elicit allergic response or to contribute to atopic disorders remains largely unexplored in pediatric patients. This study was undertaken to investigate the status and contribution of filaggrin protein, eosinophil MBP and total IgE in pediatric patients with AD, AR and BA. Methods Sera from 395 pediatric patients of AD, AR or BA with varying levels of disease activity according to the disease activity index and 410 age-matched non-atopic healthy controls were evaluated for serum levels of atopic markers, including filaggrin, eosinophil MBP and IgE. Results Serum analysis showed that filaggrin levels were remarkably high in pediatric patients with AD, followed by BA and AR, whereas its levels were low in non-atopic pediatric controls. Eosinophil MBP levels in sera of atopic patients were significantly high as compared with their respective controls, but its levels were highest in AR patients, followed by AD and BA. Total IgE in sera of AD patients was markedly high, followed by AR and BA patients, whereas its levels were low in non-atopic pediatric controls. Interestingly, not only was an increased number of subjects positive for filaggrin protein, eosinophil MBP or total IgE, but also their levels were statistically significantly higher among those atopic patients whose disease activity scores were higher as compared with atopic patients with lower disease activity scores. Conclusions These findings strongly support a role of filaggrin protein, eosinophil MBP and IgE in the onset of allergic reactions in pediatric patients with AD, AR and BA. The data suggest that filaggrin, eosinophil MBP or IgE might be useful in evaluating the progression of AD, AR or BA and in elucidating the mechanisms involved in the pathogenesis of these pediatric disorders.

【 授权许可】

Unknown