Effect of exosomal miRNA on cancer biology and clinical applications

Molecular Cancer

Quanbo Zhou¹  Jinbo Liu¹  Junmin Song¹  Zhenqiang Sun¹  Shuaixi Yang¹  Zhiyong Zhang¹  Weitang Yuan¹  Guixian Wang¹  Zhen Li¹  Ke Shi² 

[1] Department of Anorectal Surgery, The First Affiliated Hospital of Zhengzhou University;Department of Plastic Surgery, The First Affiliated Hospital of Zhengzhou University;

关键词: Exosomal miRNAs;    Cancer;    Metastasis;    Angiogenesis;    Biomarkers;   

DOI  :  10.1186/s12943-018-0897-7

来源: DOAJ

【 摘 要 】

Abstract Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and uptake of which may involve the endosomal sorting complex required for transport (ESCRT complex) and relevant proteins. After release, exosomes are taken up by neighboring or distant cells, and the miRNAs contained within modulate such processes as interfering with tumor immunity and the microenvironment, possibly facilitating tumor growth, invasion, metastasis, angiogenesis and drug resistance. Therefore, exosomal miRNAs have a significant function in regulating cancer progression. Here, we briefly review recent findings regarding tumor-derived exosomes, including RNA sorting and delivering mechanism. We then describe the intercommunication occurring between different cells via exosomal miRNAs in tumor microenvironmnt, with impacts on tumor proliferation, vascularization, metastasis and other biological characteristics. Finally, we highlight the potential role of these molecules as biomarkers in cancer diagnosis and prognosis and tumor resistance to therapeutics.

【 授权许可】

Unknown