Periosteum and development of the tissue-engineered periosteum for guided bone regeneration

Journal of Orthopaedic Translation

Tianze Sun¹  Ming Yang¹  Jing Zhang¹  Wentao Zhang¹  Zhonghai Li¹  Yantao Zhao²  Naiguo Wang³  Na Huo⁴ 

[1] Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China;Department of Orthopedics, Fourth Medical Center of PLA General Hospital, Beijing, People's Republic of China;Department of Spinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China;Institute of Stomatology, First Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China;

关键词: Biomaterials;    Bone defect healing;    Bone repair;    Osteogenesis;    Periosteum;    Tissue-engineered periosteum;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Periosteum plays a significant role in bone formation and regeneration by storing progenitor cells, and also acts as a source of local growth factors and a scaffold for recruiting cells and other growth factors. Recently, tissue-engineered periosteum has been studied extensively and shown to be important for osteogenesis and chondrogenesis. Using biomimetic methods for artificial periosteum synthesis, membranous tissues with similar function and structure to native periosteum are produced that significantly improve the efficacy of bone grafting and scaffold engineering, and can serve as direct replacements for native periosteum. Many problems involving bone defects can be solved by preparation of idealized periosteum from materials with different properties using various techniques. Methods: This review summarizes the significance of periosteum for osteogenesis and chondrogenesis from the aspects of periosteum tissue structure, osteogenesis performance, clinical application, and development of periosteum tissue engineering. The advantages and disadvantages of different tissue engineering methods are also summarized. Results: The fast-developing field of periosteum tissue engineering is aimed toward synthesis of bionic periosteum that can ensure or accelerate the repair of bone defects. Artificial periosteum materials can be similar to natural periosteum in both structure and function, and have good therapeutic potential. Induction of periosteum tissue regeneration and bone regeneration by biomimetic periosteum is the ideal process for bone repair. Conclusions: Periosteum is essential for bone formation and regeneration, and it is indispensable in bone repair. Achieving personalized structure and composition in the construction of tissue engineering periosteum is in accordance with the design concept of both universality and emphasis on individual differences and ensures the combination of commonness and individuality, which are expected to meet the clinical needs of bone repair more effectively. The translational potential of this article: To better understand the role of periosteum in bone repair, clarify the present research situation of periosteum and tissue engineering periosteum, and determine the development and optimization direction of tissue engineering periosteum in the future. It is hoped that periosteum tissue engineering will play a greater role in meeting the clinical needs of bone repair in the future, and makes it possible to achieve optimization of bone tissue therapy.

【 授权许可】

Unknown