Biological applications of copper-containing materials

Bioactive Materials

卷:6

Ke Xu¹  Yonghui Yuan²  Xun Qi³  Peng Wang⁴  Yinghui Yang⁴  Hongshan Zhong⁴  Ke Yang⁴  Shiyu Jin⁵ 

[1] Institute, Shenyang, Liaoning, 110042, China;

[2] Clinical Research Center for Malignant Tumor of Liaoning Province, Cancer Hospital of China Medical University Liaoning Cancer Hospital &

[3] Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China;

[4] Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province, Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China;

[5] Suzhou Silvan Medical Co., Ltd, Suzhou 215006, China;

关键词: Copper;    Biomaterials;    Angiogenesis;    Osteogenesis;    Antibacterial;   

DOI  :  

来源: DOAJ

【 摘 要 】

Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

【 授权许可】

Unknown