期刊论文详细信息
Nutrients
Dietary Fat Intake and KRAS Mutations in Colorectal Cancer in a Moroccan Population
Laila Chbani1  Mohammed Sekal1  Kaoutar Znati2  Ellen Kampman3  Sanae Abbaoui4  Achraf El Asri5  Btissame Zarrouq5  Meimouna Mint Sidi Deoula5  Karima El Rhazi5  Zineb Hatime5  Khaoula El Kinany5  Fatima Zahra Moufid6  Laila Bouguenouch6  Karim Ouldim6  Marc J. Gunter7  Inge Huybrechts7  Mehdi Karkouri8 
[1] Department of Anatomy and Cytopathology, Hassan II University Hospital, Sidi Mohammed Ben Abdallah University, Fez 30000, Morocco;Department of Pathology, Ibn Sina University Hospital, Mohammed V University, Rabat 10001, Morocco;Division of Human Nutrition and Health, Wageningen University and Research, 69000 Wageningen, The Netherlands;Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir 80035, Morocco;Laboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco;Medical Genetics and Oncogenetics Unit, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco;Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 69372 Lyon, France;Pathologic Anatomy and Cytology Laboratory, Ibn Rochd University Hospital, Casablanca 20360, Morocco;
关键词: colorectal cancer;    KRAS mutations;    diet;    fat intake;    Moroccan population;   
DOI  :  10.3390/nu14020318
来源: DOAJ
【 摘 要 】

Epidemiologic data support an association between diet and mutations in the Kirsten-ras (KRAS) gene involved in colorectal cancer (CRC) development. This study aimed to explore the associations between fat intake and KRAS mutations in codons 12 and 13 in cases of CRC in the Moroccan population. A multicenter case-series study nested in a large-scale Moroccan CRC case-control study was conducted. Among all CRC cases recruited, 151 specimens were available for the DNA mutation analysis. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cis) for KRAS mutation status according to the fat intake variables. A KRAS mutation was detected in the CRC tumor of 34.4% of the patients among whom 65.4% had a single mutation at codon 12 and 34.6% had a single mutation at codon 13. Compared to low levels of consumption, a positive association was observed between high polyunsaturated fatty acids (PUFA) consumption (>16.9 g/day) and prevalence of KRAS mutations (OR = 2.15, 95% CI = 1.01–4.59). No statistically significant associations were observed for total fat, monounsaturated fatty acids, saturated fatty acids and KRAS mutations. The results of this study suggest that PUFA may be relevant in the etiology of CRC, possibly through the generation of G > A transitions at the KRAS oncogene. Further studies are needed to verify and explain this finding.

【 授权许可】

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