Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain

Frontiers in Medicine

article

Guillermo García-Rayado¹  María A. Udaondo-Cascante²  María J. Soria-de-la-Cruz³  José Lariño-Noia⁴  Roberto García-Figueiras⁵  Cristina Gil-García-Ollauri⁶  Ricardo Ituarte-Uriarte⁷  Carmen L. Rosales-Alexander⁸  Jordi Soriano⁸  María Rodríguez-Peláez⁹  Alicia Mesa-Álvarez^1,10  Gregorio Varela-Moreiras^1,11  Elida Oblitas^1,12  María M. Menso^1,13  Federico Bertoletti^1,12  José I. Rodríguez-Prada^1,14  Silvia Guzmán-Suárez^1,15  Daniel Closa^1,16  Enrique de-Madaria^1,17  Ángel Lanas¹  Ángel Ferrández¹  Nelly Balza-Lareu^1,18  Juan I. Cervera²  María P. Bodenlle-Bello^1,19  Ana M. Argüelles-Arias^2,20  Patricia Latorre^2,21 

[1] University Clinic Hospital Lozano Blesa, Aragón Health Research Institute (IIS Aragón);Department of Radiology, Hospital Clínico Universitario;Department of Gastroenterology, Hospital Puerta del Mar;Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela;Department of Radiology, University Hospital of Santiago de Compostela;Department of Gastroenterology, Hospital Universitario Cruces;Department of Radiology, Hospital Universitario Cruces;Department of Gastroenterology, Hospital Universitari Doctor Josep Trueta;Department of Gastroenterology, Hospital Universitario Central de Asturias;Department of Radiology, Hospital Universitario Central de Asturias;Department of Pharmaceutical & Health Sciences, Universidad CEU San Pablo;Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau;Department of Radiology, Hospital de la Santa Creu i Sant Pau;Department of Gastroenterology, Hospital Xeral;Department of Surgery, Hospital Xeral;Department of Experimental Pathology, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS);Department of Gastroenterology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation);Department of Gastroenterology, Hospital Son LLatzer;Department of Radiology, Hospital Meixoeiro;Department of Radiology, Hospital Universitario Vírgen Macarena;Department of Gastroenterology, Hospital Universitario Doctor Peset

关键词: acute pancreatitis;    diet;    fat intake;    obesity;    unsaturated fatty acids;   

DOI  :  10.3389/fmed.2020.00126

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background/Objective: Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP). Objective: The aim of this study was to analyze outcomes in patients with AP from regions in Spain with different patterns of dietary fat intake. Materials and Methods: A retrospective analysis was performed with data from 1,655 patients with AP from a Spanish prospective cohort study and regional nutritional data from a Spanish cross-sectional study. Nutritional data considered in the study concern the total lipid consumption, detailing total saturated fatty acids, UFAs and monounsaturated fatty acids (MUFAs) consumption derived from regional data and not from the patient prospective cohort. Two multivariable analysis models were used: (1) a model with the Charlson comorbidity index, sex, alcoholic etiology, and recurrent AP; (2) a model that included these variables plus obesity. Results: In multivariable analysis, patients from regions with high UFA intake had a significantly increased frequency of local complications, persistent organ failure (POF), mortality, and moderate-to-severe disease in the model without obesity and a higher frequency of POF in the model with obesity. Patients from regions with high MUFA intake had significantly more local complications and moderate-to-severe disease; this significance remained for moderate-to-severe disease when obesity was added to the model. Conclusions: Differences in dietary fat patterns could be associated with different outcomes in AP, and dietary fat patterns may be a pre-morbid factor that determines the severity of AP. UFAs, and particulary MUFAs, may influence the pathogenesis of the severity of AP.

【 授权许可】

CC BY