Microfabrication of Embedding a Flexible Parylene-Based Microelectrode Array within Body-on-a-Chip

Proceedings

Toshiyuki Tsuchiya¹  Osamu Tabata¹  Tatsuya Omaki¹  Yoshikazu Hirai¹  Ken-ichiro Kamei² 

[1] Department of Micro Engineering, Kyoto University, Kyoto, Japan;Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan;

关键词: microelectrode array;    parylene;    flexible;    PDMS;    microfluidics;    Body-on-a-Chip;   

DOI  :  10.3390/proceedings1040302

来源: DOAJ

【 摘 要 】

To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach. Here we integrate flexible MEA into microengineered and microfluidic in vitro human models, known as “Body-on-a-Chip”, during its fabrication. In this work, Au electrodes are covered by two layers of parylene C films, and then embedded in a polydimethylsiloxane (PDMS) layer, resulting in an easy-to-integrate process and compatible with soft-lithography. For a proof of fabrication concept, the impedance of individual electrode-electrolyte interfaces are measured to show a potential for network electrophysiology.

【 授权许可】

Unknown