Proceedings | |
Microfabrication of Embedding a Flexible Parylene-Based Microelectrode Array within Body-on-a-Chip | |
Toshiyuki Tsuchiya1  Osamu Tabata1  Tatsuya Omaki1  Yoshikazu Hirai1  Ken-ichiro Kamei2  | |
[1] Department of Micro Engineering, Kyoto University, Kyoto, Japan;Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan; | |
关键词: microelectrode array; parylene; flexible; PDMS; microfluidics; Body-on-a-Chip; | |
DOI : 10.3390/proceedings1040302 | |
来源: DOAJ |
【 摘 要 】
To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach. Here we integrate flexible MEA into microengineered and microfluidic in vitro human models, known as “Body-on-a-Chip”, during its fabrication. In this work, Au electrodes are covered by two layers of parylene C films, and then embedded in a polydimethylsiloxane (PDMS) layer, resulting in an easy-to-integrate process and compatible with soft-lithography. For a proof of fabrication concept, the impedance of individual electrode-electrolyte interfaces are measured to show a potential for network electrophysiology.
【 授权许可】
Unknown