Proceedings | |
Microfabrication of Embedding a Flexible Parylene-Based Microelectrode Array within Body-on-a-Chip | |
Omaki, Tatsuya1  | |
关键词: microelectrode array; parylene; flexible; PDMS; microfluidics; Body-on-a-Chip; | |
DOI : 10.3390/proceedings1040302 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: mdpi | |
【 摘 要 】
To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach. Here we integrate flexible MEA into microengineered and microfluidic in vitro human models, known as âBody-on-a-Chipâ, during its fabrication. In this work, Au electrodes are covered by two layers of parylene C films, and then embedded in a polydimethylsiloxane (PDMS) layer, resulting in an easy-to-integrate process and compatible with soft-lithography. For a proof of fabrication concept, the impedance of individual electrode-electrolyte interfaces are measured to show a potential for network electrophysiology.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201902029772477ZK.pdf | 1608KB | download |