Health benefits of sesamin on cardiovascular disease and its associated risk factors

Saudi Pharmaceutical Journal

Amin F. Majdalawieh¹  Sarah Dalibalta²  Herak Manjikian³ 

[1] Department of Biology, Chemistry, and Environmental Sciences, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, P.O. Box 26666, United Arab Emirates;Corresponding author.;Department of Biology, Chemistry, and Environmental Sciences, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, P.O. Box 26666, United Arab Emirates;

关键词: Sesamin;    CVD;    Hypertension;    Atherosclerosis;    Thrombosis;    Diabetes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Sesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro, and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.

【 授权许可】

Unknown