The association between HIV and atherosclerotic cardiovascular disease in sub-Saharan Africa: a systematic review

BMC Public Health

Research Article

Bongani M. Mayosi¹  Mosepele Mosepele²  Virginia A. Triant³  Emily B. Martey⁴  Emily P. Hyle⁵  Rochelle P. Walensky⁶  Linda-Gail Bekker⁷  Keren Middelkoop⁷ 

[1] Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa;Department of Internal Medicine, Faculty of Medicine, University of Botswana, Gaborone, Botswana;Botswana-Harvard AIDS Partnership, Gaborone, Botswana;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA;Harvard Medical School, Boston, MA, USA;Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA;Medical Practice Evaluation Center, Massachusetts General Hospital, 50 Staniford St., 9th Floor, 02114-2696, Boston, MA, USA;Medical Practice Evaluation Center, Massachusetts General Hospital, 50 Staniford St., 9th Floor, 02114-2696, Boston, MA, USA;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA;Harvard Medical School, Boston, MA, USA;Medical Practice Evaluation Center, Massachusetts General Hospital, 50 Staniford St., 9th Floor, 02114-2696, Boston, MA, USA;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA;Harvard Medical School, Boston, MA, USA;Harvard University Center for AIDS Research (CFAR), Boston, MA, USA;Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, MA, USA;Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA;The Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa;

关键词: HIV;    CVD;    Atherosclerosis;    Africa;    Review;   

DOI  :  10.1186/s12889-017-4940-1

 received in 2017-08-04, accepted in 2017-11-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSub-Saharan Africa (SSA) has confronted decades of the HIV epidemic with substantial improvements in access to life-saving antiretroviral therapy (ART). Now, with improved survival, people living with HIV (PLWH) are at increased risk for non-communicable diseases (NCDs), including atherosclerotic cardiovascular disease (CVD). We assessed the existing literature regarding the association of CVD outcomes and HIV in SSA.MethodsWe used the PRISMA guidelines to perform a systematic review of the published literature regarding the association of CVD and HIV in SSA with a focus on CVD surrogate and clinical outcomes in PLWH.ResultsFrom January 2000 until March 2017, 31 articles were published regarding CVD outcomes among PLWH in SSA. Data from surrogate CVD outcomes (n = 13) suggest an increased risk of CVD events among PLWH in SSA. Although acute coronary syndrome is reported infrequently in SSA among PLWH, limited data from five studies suggest extensive thrombus and hypercoagulability as contributing factors. Additional studies suggest an increased risk of stroke among PLWH (n = 13); however, most data are from immunosuppressed ART-naïve PLWH and thus are potentially confounded by the possibility of central nervous system infections.ConclusionsGiven ongoing gaps in our current understanding of CVD and other NCDs in PLWH in SSA, it is imperative to ascertain the burden of CVD outcomes, and to examine strategies for intervention and best practices to enhance the health of this vulnerable population.

【 授权许可】

CC BY   
© The Author(s). 2017