Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians

BMC Cardiovascular Disorders

Yasaman Khalili¹  Maryam Hosseini Moghadam¹  Mahshid Malakootian¹  Maryam Parham²  Reza Kiani²  Parham Sadeghipour²  Elham Taheri Bajgan³  Hooman Bakhshandeh⁴  Ali Sarreshtedari⁴  Fatemeh Sehati⁴  Yeganeh Karimi⁴  Mina Mirzad⁴  Farzaneh Mehrvarz⁴ 

[1] Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences;Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences;Molecular Genetics Department, Faculty of Biological Sciences, Tarbiat Modares University;Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences;

关键词: Coronary artery disease;    Endothelial dysfunction;    Coronary slow flow phenomenon;    Endothelial nitric oxide synthase;    Interleukin-1β;    rs1799983;   

DOI  :  10.1186/s12872-022-02736-0

来源: DOAJ

【 摘 要 】

Abstract Background Mounting evidence indicates an association between endothelial dysfunction and the coronary slow flow phenomenon (CSFP). In the present study, we aimed to evaluate the possible role of endothelial nitric oxide synthase (eNOS) 894G/T and interleukin-1β (IL-1β) 315C/T polymorphisms as possible risk factors for CSFP. Methods This prospective study enrolled patients with CSFP and individuals with normal coronary arteries. Genotypes were assessed using regular polymerase chain reaction and direct Sanger-sequencing techniques. Results The study population consisted of 267 individuals: 180 patients with CSFP (49 women [27.2%]) at a median age of 55 (48–62) years and 87 controls with normal coronary arteries (56 women [64.4%]) at a median age of 47 (41–58) years. The allelic distribution of eNOS 894G/T was significantly associated with CSFP (odds ratio [OR], 1.58; 95% confidence interval (CI), 1.04–2.42; P = 0.03). This polymorphism increased the risk of CSFP under the dominant model (OR 1.73; 95% CI I.02–2.95; P = 0.04). However, the allelic frequencies (1.05; 95% CI 0.68–1.59; P = 0.83) and genotypic frequencies (0.88; 95% CI 0.52–1.49; P = 0.63) of the IL-1β 315C/T polymorphism were not associated with the incidence of CSFP in the Iranian population. Conclusions The CSFP and control groups were statistically different regarding the eNOS 894G/T polymorphism. Our findings also demonstrated that the IL-1β 315C/T polymorphism was not a risk factor for CSFP.

【 授权许可】

Unknown