Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection

Neurology International

Cesare Gagliardo¹  Antonia Pignolo¹  Paolo Ragonese¹  Giuseppe Salemi¹  Paolo Aridon¹  Maria Aprile¹  Giuseppe La Tona¹  Marco D’Amelio¹  Giovanni Maurizio Giammanco² 

[1] Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Via Gaetano la Loggia n.1, 90129 Palermo, Italy;Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, 90129 Palermo, Italy;

关键词: multiple sclerosis;    COVID-19;    relapse;    onset;    vaccine;   

DOI  :  10.3390/neurolint13040066

来源: DOAJ

【 摘 要 】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against possible reinfection. We hypothesize that SARS-CoV-2 infection, as previously reported for other viruses, could drive an active inflammatory response that can contribute either to the onset of MS or its relapse. The presented data further support the importance of vaccination in individuals with MS.

【 授权许可】

Unknown