An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

Molecules

关键词: dispirooxindole;    three-component reaction;    1,3-dipolar cycloaddition;    azomethine ylide;   

DOI  :  10.3390/molecules171112704

来源: DOAJ

【 摘 要 】

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

【 授权许可】

Unknown