Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold

Molecules

关键词: Knoevenagel condensation;    1,3-dipolar cycloaddition;    azomethine ylide;    parallel synthesis;    spiro dihydrouracils;   

DOI  :  10.3390/molecules15042269

来源: DOAJ

【 摘 要 】

The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in compounds active in the central nervous system. The b-aryl pyrrolidines are synthesized through a three-step methodology that includes a Knoevenagel condensation reaction, a 1,3-dipolar cycloaddition reaction, and a nitrile reduction.

【 授权许可】

Unknown