An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

Molecules

Zhibin Huang⁴  Qian Zhao³  Gang Chen²  Huiyuan Wang⁴  Wei Lin⁴  Lexing Xu¹  Hongtao Liu¹  Juxian Wang¹  Daqing Shi⁴ 

[1] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Xinchang 312500, China;Tianjin ShuiGe Hospital, Tianjin 300120, China;Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

关键词: dispirooxindole;    three-component reaction;    1;    3-dipolar cycloaddition;    azomethine ylide;   

DOI  :  10.3390/molecules171112704

来源: mdpi

【 摘 要 】

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.