A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

Molecules

Jun He¹  Guang Ouyang²  Zhixiang Yuan³  Rongsheng Tong²  Jianyou Shi² 

[1] State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China;Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu 610072, China;Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China

关键词: multicomponent reactions;    1;    3-dipolarcycloaddition;    azomethine ylide;    dispirooxindole;   

DOI  :  10.3390/molecules18055142

来源: mdpi

【 摘 要 】

An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.