Risk factors for multidrug-resistant tuberculosis among tuberculosis patients in Serbia: a case-control study

BMC Public Health

Maja Stosic¹  Kristie L. Foley²  Sandra Sipetic Grujicic³  Isidora Vujcic³  Dragan Babic⁴  Dejana Vukovic⁵  Gordana Antonijevic⁶ 

[1] Department of HIV/AIDS, STIs, Viral Hepatitis and TB, Public Health Institute of Serbia;Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine;Institute of Epidemiology, Faculty of Medicine, Belgrade University;Institute of Medical Statistics and Informatics, Faculty of Medicine, Belgrade University;Institute of Social Medicine, Faculty of Medicine, Belgrade University;Special Hospital for Lung Diseases;

关键词: Tuberculosis;    Multidrug –resistance;    Risk factors;    Case-control study;   

DOI  :  10.1186/s12889-018-6021-5

来源: DOAJ

【 摘 要 】

Abstract Background Multidrug resistant (MDR) tuberculosis (TB) represents TB which is simultaneous resistant to at least rifampicin (R) and isoniazid (H). Identifying inadequate therapy as the main cause of this form of the disease and explaining the factors leading to its occurrence, numerous social determinants that affect the risk of developing resistance are highlighted. The objectives of the study was to identify independent factors of MDR-TB among tuberculosis patients. Methods Case-control study was conducted from 1st September 2009 to 1st June 2014 in 31 healthcare institutions in Serbia where MDR-TB and TB patients were treated. TB patients infected with MDR- M. tuberculosis and non MDR- M. tuberculosis strain were considered as cases and controls, respectively. Cases and controls were matched by the date of hospitalization. The data was collected using structured questionnaire with face to face interview. Bivariate and multivariable logistic regression analysis (MLRA) were used to identify determinants associated with MDR-TB. Results A total of 124 respondents, 31 cases and 93 controls were participated in the study. MLRA identified six significant independent risk factors for the occurrence of MDR-TB as follows: monthly income of the family (Odds ratio (OR) = 3.71; 95% Confidence Interval (CI) = 1.22–11.28), defaulting from treatment (OR = 3.33; 95% CI = 1.14–9.09), stigma associated with TB (OR = 2.97; 95% CI = 1.18–7.45), subjective feeling of sadness (OR = 4.05; 95% CI = 1.69–9.70), use of sedatives (OR = 2.79; 95% CI = 1.02–7.65) and chronic obstructive pulmonary disease (OR = 4.51; 95% CI = 1.07–18.96). Conclusion In order to reduce burden of drug resistance, strategies of controlling MDR-TB in Serbia should emphasize multi-sectorial actions, addressing health care and social needs of TB patients.

【 授权许可】

Unknown