BMC Cancer | |
Cancer risk in tuberculosis patients in a high endemic area | |
Guang-Liang Chen1  Dong-Mei Ji2  Shun’e Yang3  Li Guo3  | |
[1] Department of Medical Oncology, Fudan University Shanghai Cancer Center, No. 270, Dong’an Road, Xuhui District, 200032, Shanghai, China;Department of Oncology, Shanghai Medical College Fudan University, No. 270, Dong’an Road, Xuhui District, 200032, Shanghai, China;Department of Medical Oncology, Fudan University Shanghai Cancer Center, No. 270, Dong’an Road, Xuhui District, 200032, Shanghai, China;Department of Oncology, Shanghai Medical College Fudan University, No. 270, Dong’an Road, Xuhui District, 200032, Shanghai, China;Phase I Clinical Trial Center, Fudan University Shanghai Cancer Center, No. 4333, Kangxin Road, Pudong New District, 201135, Shanghai, China;Department of Oncology, Xinjiang Cancer Hospital, Xinjiang Medical University, 830000, Xinjiang, China; | |
关键词: Tuberculosis; Malignant Cancer; Case-control study; | |
DOI : 10.1186/s12885-021-08391-6 | |
来源: Springer | |
【 摘 要 】
BackgroundTuberculosis (TB) may facilitate carcinogenesis. We performed a case-control study of the association between TB and cancer in Xinjiang, a high TB endemic area of China.MethodsFrom January 2016 to December 2018, a total of 45,455 patients hospitalized in Xinjiang Cancer Hospital were consecutively enrolled and divided into a malignant tumor group (n = 32,539) and a benign tumor group (n = 12,916). Patients with active and previous TB before the diagnosis of cancer were retrospectively identified in the two groups.ResultsA significantly higher proportion of TB was found in the malignant tumor group (n = 1776, 5.46%) than in the control (benign tumor) group (n = 175, 1.35%) (p < 0.0001). The highest and lowest proportions of TB in the malignant group were in patients with non-Hodgkin’s lymphoma (16.74%) and thyroid cancer (0.77%), respectively. In multivariate analysis adjusting for age, sex, and ethnicity, TB remained an independent risk factor for all cancers (odds ratio (OR) 1.68; 95% confidence interval (CI) 1.43–1.97). Furthermore, TB was associated with a significantly higher risk of non-Hodgkin’s lymphoma, cervical cancer, esophageal cancer, “other” cancers, ovarian cancer, and breast cancer. Moreover, females with TB were more likely to develop cancer than males (p < 0.0001), except for esophageal cancer and lymphoma.ConclusionTB patients have an elevated cancer risk. A screening strategy for TB should be taken into consideration before treatment in patients with some cancer types that are associated with a high proportion of TB.
【 授权许可】
CC BY
【 预 览 】
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