Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials

International Journal of Molecular Sciences

ThangaveluS. Rajan¹  Emanuela Mazzon²  Placido Bramanti²  Agnese Gugliandolo²  Luigia Fonticoli³  Francesca Diomede³  Oriana Trubiani³  GuyaD. Marconi⁴  Jacopo Pizzicannella⁵ 

[1] Department of Biotechnology, School of Life Sciences, Karpagam Academy of Higher Education, Coimbatore 641021, India;Department of Experimental Neurology, IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy;Department of Innovative Technologies in Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy;Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy;“Ss. Annunziata” Hospital, ASL 02 Lanciano-Vasto-Chieti, 66100 Chieti, Italy;

关键词: tissue engineering;    regenerative medicine;    biomaterials;    biocompatibility;    scaffold;    tissue repair;   

DOI  :  10.3390/ijms22105236

来源: DOAJ

【 摘 要 】

In the last few decades, tissue engineering has become one of the most studied medical fields. Even if bone shows self-remodeling properties, in some cases, due to injuries or anomalies, bone regeneration can be required. In particular, oral bone regeneration is needed in the dentistry field, where the functional restoration of tissues near the tooth represents a limit for many dental implants. In this context, the application of biomaterials and mesenchymal stem cells (MSCs) appears promising for bone regeneration. This review focused on in vivo studies that evaluated bone regeneration using biomaterials with MSCs. Different biocompatible biomaterials were enriched with MSCs from different sources. These constructs showed an enhanced bone regenerative power in in vivo models. However, we discussed also a future perspective in tissue engineering using the MSC secretome, namely the conditioned medium and extracellular vesicles. This new approach has already shown promising results for bone tissue regeneration in experimental models.

【 授权许可】

Unknown