Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Sulantha Mathotaarachchi¹  Serge Gauthier¹  Maowen Ba¹  Pedro Rosa‐Neto¹  Tharick A. Pascoal¹  Kok Pin Ng¹  Alzheimer's Disease Neuroimaging Initiative²  Xiaofeng Li² 

[1] Alzheimer's Disease Research UnitThe McGill University Research Centre for Studies in Aging, McGill UniversityMontrealCanada;Department of NeurologyThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingPR China;

关键词: Ventriculomegaly;    Neuropsychological test;    Biomarker;    Alzheimer's disease;    Idiopathic normal pressure hydrocephalus;   

DOI  :  10.1016/j.dadm.2017.08.001

来源: DOAJ

【 摘 要 】

Abstract Introduction The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear. Methods We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models. Results A total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [18F]fluorodeoxyglucose standardized uptake value ratio but higher amyloid burden represented by higher [18F]florbetapir standardized uptake value ratio and lower cerebrospinal fluid amyloid β 1–42 levels compared to those without ventriculomegaly. Discussion Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and/or normal pressure hydrocephalus.

【 授权许可】

Unknown