Antioxidant Therapy against Oxidative Damage of the Inner Ear: Protection and Preconditioning

Antioxidants

Jhang Ho Pak¹  Yehree Kim²  Junyeong Yi²  Jong Woo Chung² 

[1] Department of Convergence Medicine, College of Medicine, University of Ulsan and Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea;Department of Otorhinolaryngology—Head and Neck Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, Korea;

关键词: reactive oxygen species;    antioxidants;    inner ear;    preconditioning;    hair cells;   

DOI  :  10.3390/antiox9111076

来源: DOAJ

【 摘 要 】

Oxidative stress is an important mechanism underlying cellular damage of the inner ear, resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have been investigated; several experiments have shown their ability to effectively prevent noise-induced hearing loss, age-related hearing loss, and ototoxicity in animal models. Exogenous antioxidants has been used as single therapeutic agents or in combination. Antioxidant therapy is generally administered before the production of reactive oxygen species. However, post-exposure treatment could also be effective. Preconditioning refers to the phenomenon of pre-inducing a preventative pathway by subtle stimuli that do not cause permanent damage in the inner ear. This renders the inner ear more resistant to actual stimuli that cause permanent hearing damage. The preconditioning mechanism is also related to the induction of antioxidant enzymes. In this review, we discuss the mechanisms underlying antioxidant-associated therapeutic effects and preconditioning in the inner ear.

【 授权许可】

Unknown