Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment

Nutrients

Matteo Manuelli¹  Hellas Cena²  Virginia Rossi³  Michele Ghezzi³  Alessandra Bosetti³  Gian Vincenzo Zuccotti³  Rossella Lamberti³  Martina Chiara Pascuzzi³  Elvira Verduci³  Corrado Regalbuto⁴  Valeria Calcaterra⁵ 

[1] Clinical Nutrition and Dietetics Service, Unit of Internal Medicine and Endocrinology, ICS Maugeri IRCCS, 27100 Pavia, Italy;Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy;Pediatric Department, “Vittore Buzzi” Children’s Hospital, 20154 Milan, Italy;Pediatric Unit, Department of Maternal and Children’s Health, Fondazione IRCCS Policlinico S. Matteo and University of Pavia, 27100 Pavia, Italy;Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy;

关键词: obesity;    asthma;    diet;    nutrition;    nutrients;    children;   

DOI  :  10.3390/nu13113708

来源: DOAJ

【 摘 要 】

Childhood obesity rates have dramatically risen in numerous countries worldwide. Obesity is likely a factor in increased asthma risk, which is already one of the most widespread chronic respiratory pathologies. The pathogenic mechanism of asthma risk has still not yet been fully elucidated. Moreover, the role of obesity-related inflammation and pulmonary overreaction to environmental triggers, which ultimately result in asthma-like symptoms, and the importance of dietary characteristics is well recognized. Diet is an important adjustable element in the asthma development. Food-specific composition of the diet, in particular fat, sugar, and low-quality nutrients, is likely to promote the chronic inflammatory state seen in asthmatic patients with obesity. An unbalanced diet or supplementation as a way to control asthma more efficiently has been described. A personalized dietary intervention may improve respiratory symptoms and signs and therapeutic response. In this narrative review, we presented and discussed more recent literature on asthma associated with obesity among children, focusing on the risk of asthma among children with obesity, asthma as a result of obesity focusing on the role of adipose tissue as a mediator of systemic and local airway inflammation implicated in asthma regulation, and the impact of nutrition and nutrients in the development and treatment of asthma. Appropriate early nutritional intervention could possibly be critical in preventing and managing asthma associated with obesity among children.

【 授权许可】

Unknown