A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Immunity & Ageing

Yuanyuan Wang¹  Ying Yang²  Shu-Chao Pang³ 

[1] Department of Cardiology, Hangzhou Xiacheng Hospital of Integrated Traditional Chinese and Western Medicine;Department of Cardiology, SirRunRunShaw Hospital, College of Medicine, Zhejiang University;The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine;

关键词: Immunosenescence;    Elderly patients;    Cardiovascular disease;    COVID-19;   

DOI  :  10.1186/s12979-021-00234-z

来源: DOAJ

【 摘 要 】

Abstract Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a cascade of innate and adaptive immune responses in the host. The principal causes of death among COVID-19 patients, especially elderly subjects with cardiovascular diseases, are acute respiratory distress syndrome(ARDS), multiple organ dysfunction syndrome (MODS), and microvascular thrombosis. All prompted by an excessive uncontrolled systemic inflammatory response. Immunosenescence, characterized by systemic and chronic inflammation as well as innate/adaptive immune imbalance, presents both in the elderly and cardiovascular patients. COVID-19 infection further aggravates the existing inflammatory process and lymphocyte depletion leading to uncontrollable systemic inflammatory responses, which is the primary cause of death. Based on the higher mortality, this study attempts to elucidate the pathophysiological mechanisms of COVID-19 in elderly subjects with cardiovascular diseases as well as the cause of the high mortality result from COVID-19.

【 授权许可】

Unknown