Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease

Immunity & Ageing

George Wang¹  I-Yu Chen²  Chien-Sheng Wu²  Kai-Hsiang Shu²  Fang-Yun Lay²  Wan-Chuan Tsai²  Yu-Sen Peng²  Hung-Yuan Chen²  Shih-Ping Hsu²  Chih-Kang Chiang³  Feng-Jung Yang⁴  Yen-Ling Chiu⁴  Yi-Fang Chuang⁵ 

[1] Biology of Healthy Aging Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine;Department of Internal Medicine, Far Eastern Memorial Hospital;Department of Medicine, National Taiwan University Hospital;Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University;Institute of Public Health, School of Medicine, National Yang Ming University;

关键词: Cytomegalovirus;    End-stage renal disease;    Cardiovascular disease;    Immunosenescence;    Immunology;   

DOI  :  10.1186/s12979-018-0120-0

来源: DOAJ

【 摘 要 】

Abstract Background Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.

【 授权许可】

Unknown