2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

Molbank

Valeriya G. Melekhina¹  Boris V. Lichitsky¹  Andrey N. Komogortsev¹ 

[1] N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, 119991 Moscow, Russia;

关键词: multicomponent reaction;    furocoumarin;    Meldrum’s acid;    arylglyoxals;   

DOI  :  10.3390/M1304

来源: DOAJ

【 摘 要 】

For the first time, we describe a new approach towards the synthesis of previously unknown 2-(2-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic acid. The presented method is based on the multicomponent condensation of 5-hydroxy-4,7-dimethyl-2H-chromen-2-one, 4-methoxyphenylglyoxal and Meldrum’s acid. It was shown that the studied reaction proceeds in two steps including the initial interaction of starting materials in MeCN and the final formation of furylacetic acid moiety in acidic media. The structures of the obtained compound were established by ¹H, ¹³C-NMR spectroscopy and high-resolution mass spectrometry.

【 授权许可】

Unknown