Atom- and step-economic synthesis of biaryl-substituted furocoumarins, furoquinolones and furopyrimidines by multicomponent reactions and one-pot synthesis

Green Processing and Synthesis

article

Asha Kadam¹  Stephanie Bellinger¹  Wei Zhang¹ 

[1] Department of Chemistry, University of Massachusetts Boston

关键词: atom economy;    furocoumarin;    furopyrimidine;    furoquinolone;    multicomponent reaction;    one-pot synthesis;    step economy;   

DOI  :  10.1515/gps-2013-0064

来源: De Gruyter

【 摘 要 】

Atom-efficient multicomponent reactions (MCR) and step-efficient one-pot synthesis are developed for the synthesis of biaryl-substituted furocoumarins, furoquinolones, and furopyrimidines. Furocoumarin and furoquinolone derivatives are synthesized by a three-component reaction, followed by the Suzuki coupling reaction. Furopyrimidine derivatives are prepared by the Suzuki coupling and then the three-component reaction. The bromobenzaldehydes are the key bifunctional molecules for the multicomponent and Suzuki coupling reactions.

【 授权许可】

CC BY